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cibis ii trial – bisoprolol vs placebo, lancet 1999 pubmed abstract the cibis-ii study enrolled 2647 patients with heart failure main inclusion criteria symptomatic heart failure nyha class iii or iv ; ef 35 ; receiving diuretics; receiving ace inhibitor or other vasodilator if ace-intolerant main exclusion criteria uncontrolled hypertension; myocardial infarction or unstable angina within previous 3 months; pci or cabg within previous 6 months; resting pulse 60 bpm; sbp 100 mmhg baseline characteristics average age 61 years; nyha class iii – 93 , nyha class iv – 17 ; average bp – 130 80; average ef – 27 ; medications at enrollment, digoxin – 52 , diuretics – 99 , ace inhibitor – 96 patients were randomized to 1 of 2 groups group 1 1320 patients – placebo once daily group 2 1327 patients – bisoprolol – target dose 10 mg once daily bisoprolol was started at 1.

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