Specifically, digoxin inhibits sodium-potassium atpase, the enzyme controlling egress and ingress of cellular sodium and potassium.
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colestipol moderate although colestipol and cholestyramine have been reported to reduce the bioavailability of digitoxin, their effects on digoxin absorption are hypothesized to be less since digoxin undergoes less enterohepatic recycling than digitoxin.
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cibis ii trial – bisoprolol vs placebo, lancet 1999 pubmed abstract the cibis-ii study enrolled 2647 patients with heart failure main inclusion criteria symptomatic heart failure nyha class iii or iv ; ef 35 ; receiving diuretics; receiving ace inhibitor or other vasodilator if ace-intolerant main exclusion criteria uncontrolled hypertension; myocardial infarction or unstable angina within previous 3 months; pci or cabg within previous 6 months; resting pulse 60 bpm; sbp 100 mmhg baseline characteristics average age 61 years; nyha class iii – 93 , nyha class iv – 17 ; average bp – 130 80; average ef – 27 ; medications at enrollment, digoxin – 52 , diuretics – 99 , ace inhibitor – 96 patients were randomized to 1 of 2 groups group 1 1320 patients – placebo once daily group 2 1327 patients – bisoprolol – target dose 10 mg once daily bisoprolol was started at 1.
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